This case stresses the importance of early diagnosis of maxillary sinus carcinoma, in order to increase chances of survival. The tumor invaded the subdermal layers of the skin, the hard palate, and the inferior portion of the right frontal sinus. She was taken back to theatre approximately 6 weeks fol. As a rule, the lower the number, the less the cancer has spread. Maxillary sinus antrum of higmore the maxillary sinus is a pneumatic space. Information about clinical trials is available from the nci website. It is occupational mainly due to inhalation of carcinogens. Saponinfacilitatesantirobo1immunotoxincytotoxiceffectson. Both sets of patients received radiotherapy alone, or radiotherapy combined with surgery andor. Nov 18, 20 malignant neoplasms of maxillary sinus these are rare in occurrence accounting for less than 1% of all malignancies in the body. Pleomorphic adenoma arising in palatal minor salivary gland may bulge into the sinus floor and adenoid cystic carcinoma may invade it.
The sphenoid sinuses are very difficult to reach with surgery. Maxillary carcinoma the college of family physicians of. To evaluate the incidence and prognostic significance of lymph node metastasis in maxillary sinus carcinoma. Most neoplasms of the maxillary sinus remain asymptomatic and sometimes will mimic rhinosinusitis. The maxillary sinuses are the only sizable sinuses present at birth. The development of a carcinoma ex pleomorphic adenoma in the sinonasal passage is distinctly unusual. It is the largest bilateral air sinus located in the body of the maxilla and opens in the middle nasal meatus of the nasal cavity with single or multiple openings. Carcinoma ex pleomorphic adenoma of the maxillary sinus. We report a case of the patient who presented with pain and swelling in the left maxillary region. Empyema of the antrum is frequently suspected and conservative drainage instituted.
Carcinoma maxillary sinus arises from lining of maxillary sinus. The ct scan is important in assessing the extent of the tumor and demonstrating the involvement of the adjacent bony. The skin over the involved sinus can be tender, hot, and even reddened due to the inflammatory process in the. Anderson cancer center between the years 1971 and 1986. Metastasis of renal cell carcinoma rcc to the head and neck region is rare. Head and neck squamous cell carcinoma hnscc is one of the most common cancers worldwide. The treatment results were compared in 77 patients with maxillary sinus squamous cell carcinoma mc and 53 patients with squamous cell carcinoma arising from the oral part of the upper jaw oc. The primary reason for ordering ct and mri studies in cases of maxillary sinus carcinoma, is for better characterizing the invasion of structures beyond the site of origin 2. Sinonasal undifferentiated carcinoma of the maxillary sinus. They usually present late despite growing large since they remain confined to the maxillary sinus and produce no symptoms. The annual incidence is maxillary sinus observed over a 30year period.
A range of malignancies can develop in the paranasal maxillary, ethmoid, sphenoid, frontal sinuses. Epidemiology most commonly affects patients over 45. It occurs in middle aged male around 40 to 60 years old. Mucoepidermoid carcinoma of maxillary sinus pathology. Treatment options by type, location, and stage of nasal. Chemo, targeted therapy, andor immunotherapy might be used as well. Their records were evaluated according to stage, disease at presentation, symptoms and signs at presentation, treatment, and outcome. Being exposed to certain chemicals or dust in the workplace can increase the risk of paranasal sinus. Mucoepidermoid carcinoma of maxillary sinus original research paper dr. About 2030 per cent of the patients became aware of swelling of cheek, nasal obstruction, nasal discharge and epistaxis as first symptoms.
Previous studies have shown that squamous cell carcinoma in the maxillary sinus have moderate to high frequencies of neck lymph node recurrences of 10%. Different types of cells in the paranasal sinus and nasal cavity may become malignant. Squamous cell carcinoma of the maxillary sinus jama. Spindle cell carcinoma sarcomatoid carcinoma of maxillary. A medline search was performed using the term maxillary carcinoma, with the subheadings maxillary neoplasms and squamous cell carcinoma. By the time of overt signs of squamouscell carcinoma of the maxillary antrum e. Nasopharayngoscopy revealed lateral wall of the right nasal cavity was pushed medially by the mass. A diagnosis of sinonasal undifferentiated carcinoma snuc was reached. The ostium of the maxillary sinus is high up on the medial wall and on average is 2.
A retrospective study was conducted to evaluate the clinical outcomes of 11 patients with advanced squamous cell carcinoma of the maxillary sinus in. Nov 20, 2000 carcinomas of the maxillary sinus are uncommon. Squamous cell carcinoma likely originates from metaplastic epithelium of the sinus mucosal lining. Lymph node metastasis in maxillary sinus carcinoma.
The pyramidshaped maxillary sinus or antrum of highmore is the largest of the paranasal sinuses, and drains into the middle meatus of the nose through the osteomeatal complex. Squamous cell carcinoma comprising 80% to 90% of cancers in this site, most common primary neoplasm of maxillary sinus. Found in the body of the maxilla, this sinus has three recesses. Previous studies have shown that squamous cell carcinoma in the maxillary sinus have moderate to high frequencies of neck lymph node recurrences of 10% to 38%, although the majority of patients. Oral scc is typically associated with the mandible or the maxilla but will slowly invade the underlying tissues after onset. Asian countries report a very high incidence of maxillary sinus carcinoma, which makes it important for us to raise general awareness among oral stomatologists. The commonest malignancy found was squamous cell carcinoma scc 35%. The epidemiology, clinical presentation, diagnosis, and management of these tumors are discussed here. Squamous cell carcinoma of the maxillary sinus 35% vs 29%. Metastasis of papillary thyroid carcinoma to the maxillary. Pdf maxillary sinus squamous cell carcinoma is an aggressive tumor, usually diagnosed at an advanced stage and most patients present. It destroys bony walls and invades the surrounding structures. Most melanomas of the nasal cavity or paranasal sinuses are treated with surgery to remove the tumor and a rim of normal tissue around it.
The majority of patients presented with tumors classified as t 3 31. Symptoms at first onset and on initial examination were analyzed in 845 patients with maxillary sinus carcinoma. Symptoms in patients with maxillary sinus carcinoma the. Squamous cell carcinoma of the maxillary sinus and the.
We report the case of a 65yearold man with history of rcc, presented 7 years after nephrectomy, adrenalectomy and lung metastasectomy for his primary tumour, with symptoms of nasal obstruction, postnasal drip, productive cough and pressure sensation in the left maxillary sinus. The patient was given two cycles of induction chemotherapy. Commonest type of malignancy involving the maxillar sinus is squamous cell. Some stages are split further, using capital letters a, b, etc. Altthnay s 21 spindle cell carcinoma sarcomatoid carcinoma of maxillary sinus and nasal cavity with orbital involvement. Saponin facilitates antirobo1 immunotoxin cytotoxic effects. Maxillary antral carcinoma radiology reference article. If you continue browsing the site, you agree to the use of cookies on this website. Saponin facilitates antirobo1 immunotoxin cytotoxic. Benign and malignant tumors of maxillary sinus ashish.
A new case of spindle cell squamous cell carcinoma with ptosis is reporting in a 65year old turkish man. Maxillary sinus squamous cell carcinoma is an aggressive tumor, usually diagnosed at an advanced stage and most patients present with very poor prognosis and survival rate. New types of treatment are being tested in clinical trials. So far very rare cases of sarcomatoid carcinoma with maxillary origin have been reported in the pubmed based research. The earliest stage of nasal cavity and paranasal sinus cancers is stage 0, also known as carcinoma in situ cis. The patient was referred to the head and neck surgery department of a local hospital where contrastenhanced computed tomography was performed. Invasion of the maxillary sinus by local malignant disease. Maxillary sinus antrum of higmore mansoura university. Abstract malignant tumors of the paranasal sinus are uncommon, constituting less than 1% of all malignancies and 3% of all head and neck cancers. Asian countries report a very high incidence of maxillary sinus carcinoma, which makes it important for us to raise general awareness among oral.
The scan revealed significant destruction of the medial and lateral walls of the maxillary sinus as well as of the left orbital floor. Any information contained in this pdf file is automatically generated from digital material. The aim of this study is to report a carcinoma affecting the maxillary sinus of a young adult, with diagnosis only being achieved with an intraoral biopsy, after the lesion had perforated the palate bone. Oral squamous cell carcinoma scc represents 90% to 95% of all malignant neoplasms of the oral cavity. Enhanced computed tomography with slice thickness of 4 mm showed a homogenous mass infiltrating the palate, nasal cavity, and right maxillary sinus measuring approximately about 4 cm. Maxillary sinus disease the early detection of insidious maxillary sinus disease can be very important for the patients prognosis, especially in the case of malignant neoplasia. This is the first reported case in a 76yearold woman with papillary thyroid carcinoma metastasizing to the maxillary sinus alone and resected through endoscopic sinonasal surgery. The mass lesion was mainly localized in the maxillary sinus, nasal cavity and extending towards the orbital wall. On ct studies all of the cases present as soft tissue masses in the maxillary sinus cavity, with 70% to 90% of cases evidencing bony destruction 2.
Pdf lymph node metastasis in maxillary sinus carcinoma. Pdf maxillary sinus squamous cell carcinoma is an aggressive tumor, usually diagnosed at an advanced stage and most patients present with very poor. Of this group, the majority had squamous cell or undifferentiated carcinoma. The following are the various types of malignant tumors of maxillary. At the 1989 triological society meeting in san francisco, calif, drs randal c. Maxillary sinus cancer is a relatively rare neoplasm with an incidence representing a small percentage 0. Antibody therapy against cancerspecific antigens is. Malignant neoplasms of maxillary sinus these are rare in occurrence accounting for less than 1% of all malignancies in the body. Maxilla sinus cancer an overview sciencedirect topics. Treatment of maxillary sinus carcinoma le 1999 cancer. Maxillary sinus carcinoma comprises about 59% in this study. The primary symptom frequently furnishes valuable evidence in determining the origin of the growth. It is classically regarded as an adult disease entity and has a high correlation with alcohol and tobacco consumption. Sinus remains silent for a long time or showing only symptoms of sinusitis.
Eightyfive patients with squamous cell cancer of the maxillary sinus received all of their treatment at the university of texas m. The symptoms of sinusitis are headache, usually near the involved sinus, and foulsmelling nasal or pharyngeal discharge, possibly with some systemic signs of infection such as fever and weakness. The skin over the involved sinus can be tender, hot, and even reddened due to the inflammatory process in the area. A tenyear experience dragoljub popovic, dusan milisavljevic clinic of otorhinolaryngology, clinical center, faculty of medicine, nis, serbia summary. To view the details of this license, please visit licensesbyncnd4. The nasal cavity and paranasal sinuses are the site of origin of more complex, histologically diverse group of. Cancers in this location are generally treated with radiation therapy. Paranasal sinus and nasal cavity cancer is a disease in which malignant cancer cells form in the tissues of the paranasal sinuses and nasal cavity. Treatment for paranasal sinus and nasal cavity cancer may cause side effects. The caudal maxillary sinus is readily accessed for sinoscopy via the frontal approach if direct access to the maxillary sinus is required, or if the sphenopalatine sinus is the area of primary interest, then the portal should be located on the dorsolateral side of the face, 2 cm rostral and 2 cm ventral to the medial canthus of the eye fig.
Squamous cell carcinoma likely originates from metaplastic epithelium of the sinus. Because of difficult histology and inconclusive margins, close clinical surveil. Paranasal sinus and nasal cavity cancer is a type of head and neck cancer. The bone window is much larger but the effective ostium is reduced by the uncinate process, an. More than 90% will have invaded through at least onewall of the involved sinus when discovered. The optimal treatment of maxillary sinus carcinoma remains to be defined and there is a paucity of. Due to the advanced stage at which it was presented and the involvement of vital structures, the patient was subjected to. Carcinoma of the antrum may produce signs referable to the nose, orbit, or teeth, long before an associated neoplasm is suspected. Maxillary antral carcinomas are an uncommon head and neck malignancy.
Both sets of patients received radiotherapy alone, or radiotherapy combined with surgery andor chemotherapy. May, 2018 maxillary sinus squamous cell carcinoma is an aggressive tumor, usually diagnosed at an advanced stage and most patients present with very poor prognosis and survival rate. Renal cell carcinoma metastases to the maxillary sinus bmj. P pdf maxillary sinus carcinoma outcomes over 60 years. Ad, magnetic resonance images show an extensive, partially enhancing, infiltrating, undifferentiated small cell carcinoma of the anteromedial walls of the maxillary sinus. Rao devineni, st louis, mo, presented a retrospective study of 148 patients with primary malignancies of the maxillary sinus observed over a 30year period. Adenocarcinoma and squamous cell carcinoma of the maxillary sinus and ethmoid sinus are the most common of these tumors. Malignant tumors of the nasal cavity and paranasal sinuses are rare, with poorly differentiated squamous cell carcinoma of the maxillary sinus being the most. A unilateral maxillary sinus tumor oman medical journal. Optimal treatment policies of maxillary sinus carcinoma remain to be defined. They comprise less than 1% of all malignancies, with poorly differentiated squamous cell carcinoma being the most common. Paranasal sinus and nasal cavity cancer treatment adult.
Lymph node metastasis in maxillary sinus carcinoma request pdf. Biopsy of the right nasal septal lesion showed a papillary carcinoma in situ, compatible with an origin in a schneiderian papilloma figure 3a. Maxillary sinusitis is inflammation of the maxillary sinuses. The purpose of this study is to report a case of a maxillary sinus carcinoma, which invaded the orbit, in a female patient, aging 46 years, who was admitted in neurosurgery clinic with a nonaxial. May 06, 2014 maxillary sinus carcinoma slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Squamous cell carcinoma of the maxillary sinus and the oral. Squamous cell carcinoma was the commonest reported tumour affecting the maxillary and ethmoid sinuses 6. Maxillary carcinoma the college of family physicians of canada. Malignant tumors of the nasal cavity and paranasal sinuses are rare, comprising less than 1% of all malignancies, with poorly differentiated squamous cell carcinoma of the maxillary sinus being the most common. Metastasis of the thyroid carcinoma to the paranasal sinuses is rarely reported. Maxilla sinus carcinoma an overview sciencedirect topics. Maxillary sinus neoplasms are relatively rare in united states and are more common in asia and africa. In a study of 492 tumors of minor salivary gland origin, spiro et al found only a single case of carcinoma ex pleomorphic adenoma that involved the maxillary sinus.
Carcinoma maxillary sinus tumor spread and treatment. Tumors of the upper jaw spread easily into the sinus. Among these sinuses, metastasis to the maxillary sinus alone has been reported only in a few cases. The purpose of this study is to report a case of a maxillary sinus carcinoma, which invaded the orbit, in a female patient, aging 46 years, who was admitted in neurosurgery clinic with a. Maxillary sinus squamous cell carcinoma noriko komatsu, 1,2 miku komatsu, 3 riuko ohashi, 4,5 akira horii, 3 kazuto hoshi, 1 tsuyoshi takato, 1,6 takahiro abe, 1 and takao hamakubo 2.
1217 1355 1011 1411 625 972 739 745 1010 613 776 1028 281 115 876 595 302 376 1265 1327 180 342 401 534 1029 1370 471 1234 1292 995 878 40 426 840 217 216 519 1213 548 1427 1102 50 1436 102 884 720 1451 171 332